Application of the hottest international neutral g

2022-08-09
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Application of international neutral glass in pharmaceutical packaging

International neutral glass is commonly referred to as class I glass, and some in China call it 5 0 glass or grade a material. This kind of glass has been widely used in the field of pharmaceutical packaging because of its good material and performance, especially its excellent chemical stability and thermal stability. At present, international neutral glass has been widely recognized by the international pharmaceutical packaging market, except for a few countries such as China and India that have not fully adopted it. After joining the WTO, China's pharmaceutical industry is facing a situation of full integration with the international market. In order to speed up the integration of China's drugs and their packaging materials with international standards as soon as possible and enable the effect powder to maintain the size and color effect to the maximum extent, resist the huge impact brought by the entry of international pharmaceutical products and packaged products into the Chinese market, and ensure the safety and effectiveness of drugs, The process of actively promoting the use of international neutral glass in the field of pharmaceutical packaging has become an urgent major issue. This paper intends to introduce the relevant standards, applications and development of international neutral glass

development overview of international neutral glass

at the end of the 19th century, the development of modern medicine urgently needs a glass container that can be stored with the liquid medicine for a long time without chemical reaction. Its main requirements are: the long-term contact between the glass container and the liquid medicine will not cause the change of pH value, and there will be no precipitation or glass chips falling off. Therefore, this kind of glass is called neutral glass. This kind of glass was invented by Schott company in Germany in 1910, and then it was invented and produced in the United States, Japan and other countries. With the continuous development and improvement of glass manufacturing technology, the application field of pharmaceutical neutral glass has been expanded and its performance has become more prominent. China sometimes adopts casting structure (cast steel, cast aluminum, etc.). Since the 1950s, many enterprises have introduced German Schott company and Japanese ne respectively. In order to gain a foothold in the new material market, G company, Corning company of the United States and other world advanced countries' production equipment and precision screw pair transmission; 2. Ordinary belt transmission process and technology. However, limited to the national conditions at that time, due to the problems of low qualification rate, high cost, low product price and manufacturing technology, the development, production and application of international neutral glass in China have not been effectively solved. In the 1960s, due to the rapid development of the domestic pharmaceutical industry, the demand for injection glass container packaging increased sharply. Domestic enterprises developed and produced low borosilicate glass, which can basically meet the requirements of drug use at that time, that is, commonly known as grade B material. Because this kind of glass material adapts to the domestic production equipment and process, with low cost and high output, it basically meets the demand of China's drug output at that time. Therefore, this kind of glass has been used in China until now, and has become an important reason why China's pharmaceutical glass cannot be in line with international standards. Although this kind of glass has played a historic role in promoting the development of pharmaceutical packaging, in essence, this kind of glass can only be a substitute for the degradation of grade, quality and performance of pharmaceutical neutral glass. In the face of today's international market of economic globalization, the rapidly developing pharmaceutical industry, and various new drugs that are constantly on the market, China's pharmaceutical glass industry should develop and produce international neutral glass that can be in line with international standards as soon as possible, and gradually restrict and eliminate the low borosilicate glass that has been used in China

international standard and performance of neutral glass

international standard ISO 12775 - 1997 "normal mass production glass classification by composition and its test methods" clearly divides medicinal glass into three kinds:

3 3 borosilicate glass

the linear thermal expansion coefficient of this glass is: α= (3. 3 ±0. 1) × 10 (- 6) K (- 1) (20 ~ 300 ℃)

its chemical composition is: SiO-2 ≈ 81% b-2o-312 ~ 13%r-2o ≈ 4% al-2o-32 ~ 3%

neutral glass

the linear thermal expansion coefficient of this glass is:

α= (4~5) × 10 (- 6) K (- 1) (20 ~ 300 ℃) its chemical composition is:

SiO-2 ≈ 75% b-2o-3 8 ~ 12%r-2o 4 ~ 8%ro

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